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Examples of such adverse events include opioid overdose occurring when sustained-release morphine products are crushed, abnormal movements occurring when sustained-release levodopa-carbidopa is crushed and the loss of efficacy of medications such as omeprazole, which are destroyed by stomach acid when crushed (Cornish 2005; Wright 2002a, 2002b).

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The extra dose function should be set at 1 mL (20 mg of levodopa) when starting DUOPA.

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It is unknown if this medication passes into breast milk.

Dysfunction of alpha-synuclein appears to play a central role in the pathogenesis of Parkinson disease, and understanding its relationship to the disease process holds major promise for the development of a cure.

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Each point has led to low national MTM completion rates.

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